A Double‐Edged Sword: Complement Component 3 inToxoplasma gondiiInfection

Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis

We molecularly dissected leptomeningeal metastasis, or spread of cancer to the cerebrospinal fluid (CSF), which is a frequent and fatal condition mediated by unknown mechanisms. We selected lung and breast cancer cell lines for the ability to infiltrate and grow in CSF, a remarkably acellular, mitogen-poor metastasis microenvironment. Complement component 3 (C3) was upregulated in four leptomen...

First Component of Human Complement

The active esterase hydrolyzed certain synthetic amino acid esters, among which N-acetyl-L-tyrosine ethyl ester was most susceptible (3-5). This substrate was hydrolyzedmaximally between pH 7.5 and 8.2 and at 41°C. The esterase was inhibited by a heat-labile factor in human serum which did not appear to be related to any of the known components of complement, and by certain sulfbydryl-containin...

Complement component 3 is a prognostic factor of non‑small cell lung cancer.

Lung cancer is the leading cause of cancer‑related mortality worldwide. The complement component 3 (C3) is a central protein of the complement system, expressed in numerous cancer tissues and considered crucial for tumor progression. This study aimed to investigate the prognostic value of C3 in non‑small cell lung cancer (NSCLC) and the underlying mechanisms. We used immunohistochemistry to obs...

Homologue of the Complement Component C 3 Sea Urchin Coelomocytes Specifically Express a

Gender specific association of a complement component 3 polymorphism with polypoidal choroidal vasculopathy

Neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are leading causes of irreversible blindness in developed countries. In this study, we investigated the associations of haplotype-tagging single nucleotide polymorphisms (SNPs) in the complement component 3 (C3) gene with both neovascular AMD and PCV, and potential epistatic effects on C3. Eight taggi...